“Therefore, anyone who refuses to live by these rules is not disobeying human teaching but is rejecting God, who gives his Holy Spirit to you.”
1 Thessalonians 4.8 NLT
Paul’s subject was apostolic commands, v. 2, and holiness, v. 3, which means keeping away from sexual immorality v. 4-5, and not defrauding one’s brother, vv. 6-7.
Rejecting God by disobedience will not end well. Unholiness does not befit people who have received the Holy Spirit. Wisdom is recognizing when God speaks.