One of the bleakest passages found in the Bible is found in Romans 1:24, where the phrase “gave them up” is found. The phrase is again repeated in verse 26 and 28, emphasizing the fact that when God gives an individual (or individuals) up, there’s no hope for that individual. Through the power of choice (Joshua 24:15), they have determined and sealed their own eternal destiny.
In his commentary on Romans http://www.searchgodsword.org/com/bcc/view.cgi?book=ro&chapter=001, Brother Burton Coffman provides the following comment regarding this phrase:
“These dreadful words, thrice repeated with increasing intensity, are a kind of litany of the doomed, showing how dreadful is the fate of them that are given up of God, that is, handed over to the consequences of their rebellion.”
When God gives us up, there is no bleaker moment.